ABSTRACT
The recent scenario with an outbreak of novel coronavirus has led to dramatic upsurge in mortality and morbidity rates all around the globe. The objective of consolidated article is to provide an updated insight on coronavirus disease (COVID-19) based on the current literature, and it is anticipated that it may serve as a perspective reference in future studies. Scopus, Science Direct, MEDLINE, PubMed, and Google Scholar databases were used to search the literature. For the current review, both research and review articles issued in the English language were considered. The mode of Corona virus disease transmission is through direct contact or inhalation of infected respiratory droplets. The length of period of incubation varies from 2 to 14 days with maximum patients presenting mild symptoms and sign, that is, cough, fatigue, fever, and sore throat. The infection could be worst and life threatening in elderly and immuno-compromised patients. Special diagnostic molecular tests are available for detection and identification of virus. Till date, no cure is available and treatment of patients is only supportive therapy. Preventive measures such as physical isolation, hand washing, and wearing of mask should be followed. Even though, strict measures are taken into account, prevalence of COVID-19 continues to escalate worldwide and coming course of this novel virus is still not known.
ABSTRACT
COVID-19 is a global pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Being associated with high mortality rates, this pandemic has forced several countries worldwide to impose complete lockdowns to limit the spread of infection. Despite the development of various vaccines, there is still an urgent need to design novel treatments backed with safety data for fighting SARS-CoV2 and its various mutants. Currently, scientists are putting their strenuous efforts into finding the best treatment option for COVID-19. In this regard, metal complexes being active antiviral agents and immunity enhancers have great potential against SARS-CoV-2. Herein, metal complexes' therapeutic role and significance against treating SARS-CoV-2 or any of its target proteins are discussed.
ABSTRACT
Background: COVID-19 is an emerging infectious disease and has reached a status of global health emergency. It is widespread in Pakistan causing morbidity and mortality amongst masses. Objectives: Undertaken study aims at investigating knowledge, attitude and practices of the people residing in Lahore, Pakistan whilst the global crisis with sparse data available previously. Methodology: Following lockdown announcement, an immediate online cross sectional study was conducted from the 31st March to 6 April 2020. Data was analyzed by using SPSS IBM version 22. 00. Results: A total of 316 responses were received. Our study has shown that people 95.80% were well familiar with COVID-19, informed via news channels 46.2%. 91.7% believed the virus is contagious, 95.8% reported that the virus is spread by the respiratory droplets, 89.2% believed that all ages are at risk while 62.3% believed it risky for geriatrics only. 60.4% believed in its prevention with 91.7% respondents agreeably quarantined themselves while 6.6% didn’t. 99.7% participants were aware of social/physical distancing and 75.6% found it affecting mental health i.e. cause anxiety, depression etc. 59.2% of respondents were optimistic expecting it to end soon while 32.3% were uncertain. 49.1% said they have diagnostic facility and 89.6% acknowledged efforts of researchers/healthcare providers (doctors, pharmacist, nurses, allied health professionals and paramedical staff) for the society. 94.3% believed that there is need of awareness regarding COVID-19. Conclusion: An ever increasing need of awareness amongst the local population regarding COVID-19 is needed. It will lend hands in preventing spread of COVID-19 with minimal secondary transmission. It is recommended that extensive survey studies are required that can provide supportive data in developing and implementing public health policies regarding COVID-19 pandemic. It would further control and arrest the spread of COVID-19 in country.